Collagen

Medical Grade Collagen

Medical grade high purity collagen

Collagen Solutions develops and produces medical grade collagen as biomaterials for research, medical equipment and regenerative medicine. Raw materials are sourced from Australia and New Zealand where there is no risk of mad cow disease under strict environmental management and animal husbandry regulations. Its superior quality is recognized by major medical device manufacturers around the world.

* Research Use
* Research Use

Pepsin Solubilized Atelocollagen

Pepsin solubilized atelocollagen

It is solubilized collagen (atelocollagen) from which telopeptide region is removed by pepsin treatment of high-purity collagen derived from bovine dermis. Ideal for cell culture, regenerative medicine research, scaffolding for 3D culture, and coating of plastic culture containers.

  • Medical grade high purity collagen
  • European Pharmaceutical Quality Council (EDQM) certified
  • Composition: Type I collagen (including about 5% type III collagen)
  • Filtration: sterile filtration (0.2 micron)
  • Solvent: 0.01N HCl (pH2)
  • Concentration: 3mg / mL, 6mg / mL
  • Packaging: 20mL, 100mL, 1000mL
  • Storage temperature: 2 ~ 8 ℃
  • Expiration date: 2 years from the date of manufacture
* Research Use
* Research Use

Acid Solubilized Telocollagen

Acid solubilized telocollagen

Acid-solubilized collagen (telocollagen) extracted from bovine dermis with high-purity collagen. By retaining the telopeptide, it forms a gel with higher viscosity and strength than pepsin-solubilized atelocollagen. Ideal for 3D cell culture, regenerative medicine research, and plastic culture container coating.

  • Medical grade high purity collagen
  • European Pharmaceutical Quality Council (EDQM) certified
  • Composition: Type I collagen (including about 5% type III collagen)
  • Filtration: sterile filtration (0.2 micron)
  • Solvent: 0.01N HCl (pH2)
  • Concentration: 6mg / mL
  • Packaging: 20mL, 100mL, 1000mL
  • Storage temperature: 2 ~ 8 ℃
  • Expiration date: 2 years from the date of manufacture

Titration Buffer

Titration buffer

0.2M, pH 11.2 titration buffer. Necessary when forming 3D gels for cell culture from pepsin-solubilized atelocollagen or acid-solubilized telocollagen.

  • Characteristics: 0.2M, pH11.2
  • Filtration: sterile filtration (0.2 micron)
  • Packaging: 20mL, 100mL
  • Storage temperature: 15 ~ 22 ℃

Collagen Powder (Telocollagen)


Collagen derived from bovine dermis

  • pH6
  • Type I collagen (including about 5% type III collagen)
  • Ideal for custom formulations, unsuitable for gel formation
  • Store in a cool and dry place


Polymeric collagen derived from bovine tendon

  • pH5 ~ 7 (Possible to supply pH2 ~ 3)
  • Type I polymeric collagen (insoluble)
  • Ideal for custom formulations, unsuitable for gel formation
  • Store in a cool and dry place温・乾燥した場所に保管
  • Both powder and sheet can be supplied

Fibrillar Collagen (Atelocollagen)


Microfiber collagen

High-purity collagen derived from bovine dermis that is optimal for cell and drug delivery and for the treatment of trauma.

Degenerate within 30 days inside the body. Concentration and pH value can be adjusted.

  • pH7 
  • Type I collagen (including about 5% type III collagen) 
  • Concentration: 65 mg / mL
  • Filtration: sterile filtration 
  • Storage temperature: 2 ~ 8 ℃
  • Can be supplied with a 1 mL syringe
  • Large supply possible


Acid Swollen Gel (Telocollagen)


Acid swelling gel

  • Derived from bovine dermis
  • Concentration: 10mg / mL
  • pH3
  • Type I collagen (including about 5% type III collagen)
  • Ideal for custom formulations, unsuitable for gel formation
  • Storage temperature: 2 ~ 10 ℃管温度:2~10℃
  • Available in 100mL and 1,000mL

Pericardium (Harvested Tissue)


Collected tissue pericardium

Compliant with quality and compliance (strict adherence requirements) for various medical applications.

  • Minimal processing and bonding
  • Many thickness and physical properties
  • Frozen or freshness maintenance packaging
  • Filtration: sterile filtration
  • Analysis of suture force, electron microscopy, mechanical properties, cross-linking, etc.


Traceability and Regulatory Advantage

Meet traceability and regulatory standards

Collagen raw materials are procured from Australia and New Zealand, certified by EDQM (European Pharmaceutical Quality Council),

Manufactured under strict quality control that meets international regulatory standards of FDA, GMP, ISO13485 and ISO22442.

U.S. Food and Drug Administration
U.S. Food and Drug Administration
European Directorate for the Quality of Medicines
European Directorate for the Quality of Medicines
ISO13485 (Scotland)
ISO13485 (Scotland)
ISO13485 (New Zealand)
ISO13485 (New Zealand)

Applications for Collagen

Application of collagen to the medical field

3D Gel from Soluble

Collagen using Titration Buffer

3D gel formation for cell culture

Optima Inc.

1-48-11 Itabashi, Itabashi-ku, Tokyo 173-0004

TEL : 03-5375-2351  |  FAX : 03-5375-2360  |  E-mail : optima@optima-japan.jp

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